"Low Protein Intake Is Associated with a Major
Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger
but Not Older Population"


Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we examined links between protein intake and mortality. Respondents aged 50-65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer death risk during the following 18 years. These associations were either abolished or attenuated if the proteins were plant derived. Conversely, high protein intake was associated with reduced cancer and overall mortality in respondents over 65, but a 5-fold increase in diabetes mortality across all ages. Mouse studies confirmed the effect of high protein intake and GHR-IGF-1 signaling on the incidence and progression of breast and melanoma tumors, but also the detrimental effects of a low protein diet in the very old. These results suggest that low protein intake during middle age followed by moderate to high protein consumption in old adults may optimize healthspan and longevity.





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1 Comment so far

  1. Leonardo on March 6, 2014 9:41 am

    Talk about a poorly and biased executed study;

    1) humans are not mice. The latter being generally omnivores, consequently giving them animal protein is bound to have a different metabolic impact

    2) Carbs have the same capacity on triggering IGF-1 cell division as protein

    3) Mice fed the high protein diet in this study were given 50% protein of their total caloric intake. Who in their right mind would eat such a high amount of proteins? Not even body-builders do so.

    4) Those who carried-out this research had vested interest in plant based protein, which surprise surprise, they recommend at the end of their study


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