Mar

16

 A wonderful and brilliant husband and wife team of neuroscientists, Gavin Rumbaugh and Courtney Miller, from the Scripps Institute in Florida, gave a very good summary at the Four Arts Society in Palm Beach of research and findings related to memory loss and Alzheimer's disease.

Things I learned included:

1. It presently takes hundreds of millions of dollars and approximately 14 years to go through about 10,000 potential drug candidates in order to get 1 drug to market.

2. Inserting luminescent genes has made it possible for computers to accurately count the development and location of new, active nerve synapses. This is important in order to more quickly test the effectiveness of new drugs on the regeneration of nerve synapses.

3. Learning or knowing a second language is helpful in the development of additional synaptic pathways so that if you loose one you will have a backup and retain your memory.

4. Getting out of routines can make the brain work harder and improve brain health. Simple things like wearing a watch on your right wrist instead of the left wrist seem to create new pathways. One guesses that hitting or throwing a ball with the left hand (if right-handed and vice versa) would be equally challenging.

5. Rumbaugh gave an overview of amazing compounds in the developmental stage that show promise in countering Alzheimer's. The basic idea is that histones can shut down the actions of genes that are important to the development of new synapses–remove the histones and memories can come back. (Kilgore M, Miller CA, Haggarty SJ, Sweatt JD, Rumbaugh G. (2010) Class 1 histone deacetylase inhibitors reverse contextual memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 35: 870-880) 

6. Diet, exercise, and good sleep (dark, cool room devoid of any artificial light source would be conducive) also important to brain health.

7. Dr. Rumbaugh and Dr. Miller invited all to visit their labs and look at things under the microscope. I may have to take them up on that. They said they are not in it for the money but are trying to do research that will be helpful to mankind. Footnote: One wonders if increased dietary intake of cruciferous vegetables, saffron, and healthy fiber to improve the gut biome would not be helpful for HDAC inhibition and thus body and brain health.

There is research that suggests so: "A diet high in fiber promotes colon health, and commensal bacteria in the gut may be protective against colon cancer. The bacterium Butyrivibrio fibrisolvens ferments fiber into short-chain fatty acids such as butyrate. Butyrate is an inhibitor of histone deacetylases (HDACs), which function in the epigenetic control of gene expression."


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